Etomidate

Etomidate(Amidate, USAN, INN, BAN) it is a short-acting anesthetic that is administered intravenously for general anesthesia and sedation in medicine. This drug is used for the reduction of sutures, tracheal intubation, electroconvulsive therapy, cardioversion. It was first synthesized in 1964 by Janssen Pharmaceuticals and began to be used for medical purposes in the EU in 1972, in 1983 in the USA.

Etomidate has a safe profile of cardiovascular risk of diseases, since it does not cause a strong drop in blood pressure, and is also used with limited suppression of ventilation, due to the lack of histamine release, as protection against myocardial ischemia.

Etomidate also has positive characteristics for people with traumatic brain injury, as it is able to reduce intracranial pressure. Etomidate has been found to inhibit the enzymatic biosynthesis of steroid hormones, and becomes useful when rapid control of hypercortisolism is needed.

This drug was used in executions in the United States, as one of the drugs. With regular administration of etomidate (more than 3-5 days), it leads to dysfunction of the adrenal cortex.

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